Use of Enzymes in the Dissolution Testing of Gelatin Capsules (Live Webcast)

April 4, 2024 10:30 am
April 4, 2024 12:00 pm
Live Online Webcast

Course Description:
This webinar discusses the procedure to be used in the dissolution testing of gelatin capsules when they fail the two-tier dissolution test. The webinar will include discussion of crosslinking in gelatin, its causes and prevention; quality requirements of the enzymes to be used and the procedure to determine their activity; and alternative procedures when the dissolution medium contains surfactants. A report on the activities related to the revision of this procedure in USP General Chapter <711> Dissolution will be presented.
Upon completion of this course, you will be able to:

  • Learn to identify the presence of crosslinking in gelatin capsules and possible ways of avoiding it
  • Learn to run the dissolution test of gelatin capsules in the presence of crosslinking
  • Understand the key elements:
  • Determination of enzymatic activity for pepsin and pancreatin
  • Procedure to be used when the dissolution medium contains surfactants

Who Should Participate:

  • Analysts who develop and/or execute dissolution testing of gelatin capsules.
  • Formulators who are developing products in gelatin capsules.
  • Materials managers who receive and store empty gelatin capsules.
  • Stability studies managers who coordinate the studies of finished products filled into gelatin capsules.