Share your feedback! Take the short survey on the new Dissolution Performance Verification Standard – Prednisone (DPVS-Prednisone) now
Share your feedback! Take the short survey on the new Dissolution Performance Verification Standard – Prednisone (DPVS-Prednisone) now

Share your feedback!

Take a short survey on the new Dissolution Performance Verification Standard – Prednisone (DPVS-Prednisone) now.

Take survey now

https://www.usp.org/sites/default/files/usp/video/reference-standards/landing-loop-no-text-1600x400.mp4
dissolution landing page loop

The new standard for Performance Verification Testing is now official as of May 1, 2023

USP General Chapter < 711> Dissolution revisions are now official and the new USP DPVS – Prednisone is the official Reference Standard

Buy DPVS – Prednisone

Performance Verification Test

Performance Verification Test (PVT)

The USP Performance Verification Test (PVT) assesses the suitable performance of apparatus used in dissolution testing.

Learn more

Previous Next

Dissolution and Drug Release Tests

Dissolution is the process in which a substance forms a solution. Dissolution testing measures the extent and rate of solution formation from a dosage form, such as tablet, capsule, ointment, etc. The dissolution of a drug is important for its bioavailability and therapeutic effectiveness. Dissolution and drug release are terms used interchangeably.

To properly evaluate the dissolution of drug products, it is critical for procedures to be standardized. This standardization helps to show consistent quality in production and may serve as a predictive measure of efficacy.

A dissolution test uses an apparatus with specific test conditions in combination with acceptance criteria to evaluate the performance of the product. General chapter <711> Dissolution includes 4 standardized apparatus: basket, paddle, reciprocating cylinder, and flow-through cell. Where specified in a monograph, USP dissolution tests are legal requirements. USP training and service are designed to help you meet regulatory compliance requirements while strengthening your quality standards.

two-right-left
Dissolution Methods Database
Dissolution Methods Database

Provides dissolution test conditions and a helpful search function in a downloadable database.

two-right-left
Performance Verification Test (PVT)
PVT

The PVT assesses dissolution apparatus performance using the USP reference standard material and procedures. This page includes resources that may be used for the PVT. The PVT is an integral part of USP General Chapter <711> Dissolution.