How to Use the USP–NF Errata Table

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Monograph Title Section Source Publication Page Number Errata Official Date Target Errata Print Publication Target Online Fix Publication Description
AMINOBENZOIC ACID IMPURITIES/Organic Impurities USP37–NF32 1730 01-Apr-2015 USP39–NF34 USP39–NF34
Add the subsection:
Standard stock solution: 0.25 mg/mL each of USP Benzocaine RS and 4-nitrobenzoic acid in methanol
AND
Line 2 of Standard solution: Change
in Mobile phase
to:
in Mobile phase, from the Standard stock solution





Add the subsection:
Standard stock solution: 0.25 mg/mL each of USP Benzocaine RS and 4-nitrobenzoic acid in methanol

AND
Line 2 of Standard solution: Change
in Mobile phase

to:
in Mobile phase, from the Standard stock solution

ASPARTAME ASSAY/Procedure USP37–NF32 5857 01-Apr-2015 USP39–NF34 USP39–NF34
Line 3 of Analysis: Change
crystal violet
to:
crystal violet TS


Line 3 of Analysis: Change
crystal violet
to:
crystal violet TS

BETAMETHASONE DIPROPIONATE ASSAY/Procedure USP37–NF32 1961 01-Apr-2015 USP39–NF34 USP39–NF34
Line 2 of Sample solution: Change
5.0 mL each of the Internal standard solution and the Standard stock solution
to:
5.0 mL each of the Internal standard solution and the Sample stock solution


Line 2 of Sample solution: Change
5.0 mL each of the Internal standard solution and the Standard stock solution

to:
5.0 mL each of the Internal standard solution and the Sample stock solution

BISMUTH SUBCARBONATE IMPURITIES/Limit of Lead USP38–NF33 2449 01-Apr-2015 USP39–NF34 USP39–NF34
Line 1 of Acceptance criteria: Change
Meets the requirements
to:
NMT 0.002%


Line 1 of Acceptance criteria: Change
Meets the requirements
to:
NMT 0.002%

BUTORPHANOL TARTRATE NASAL SOLUTION IMPURITIES/Organic Impurities First Supplement to USP37–NF32 6596 01-Apr-2015 USP39–NF34 USP39–NF34
Row 3 of Column 1 of Table 1: Change
6-Butorphanol
to:
Δ6-Butorphanol


Row 3 of Column 1 of Table 1: Change
6-Butorphanol
to:
Δ6-Butorphanol

CISATRACURIUM BESYLATE INJECTION ASSAY/Procedure USP38–NF33 2830 01-Apr-2015 USP39–NF34 USP39–NF34
Line 11 of Analysis: Change
CS = concentration of USP Cisatracurium Besylate RS in the Standard solution
to:
CS = concentration of USP Cisatracurium Besylate RS in the Standard solution (mg/mL)


Line 11 of Analysis: Change
CS
= concentration of USP Cisatracurium Besylate RS in the Standard solution

to:
CS
=
concentration of USP Cisatracurium Besylate RS in the Standard solution (mg/mL)

CLARITHROMYCIN TABLETS IMPURITIES/Organic Impurities/Chromatographic system USP38–NF33 2850 01-Apr-2015 USP39–NF34 USP39–NF34
Line 1 of Column: Change
4.6-mm × 10-cm; 3-µm packing L1
to:
4.6-mm × 10-cm; 3.5-µm packing L1


Line 1 of Column: Change
4.6-mm × 10-cm; 3-µm packing L1
to:
4.6-mm × 10-cm; 3.5-µm packing L1

COSYNTROPIN SPECIFIC TESTS/UV Absorption Spectrophotometry USP38–NF33 2958 01-Apr-2015 USP39–NF34 USP39–NF34
Line 1 of Sample solution: Change
hydrochloride
to:
hydrochloric acid


Line 1 of Sample solution: Change
hydrochloride
to:
hydrochloric acid

COSYNTROPIN IDENTIFICATION/B. Amino Acid Analysis USP38–NF33 2958 01-Apr-2015 USP39–NF34 USP39–NF34
Line 8 of Sample hydrolysate preparation: Change
hydrochloride
to:
hydrochloric acid


Line 8 of Sample hydrolysate preparation: Change
hydrochloride
to:
hydrochloric acid

FERRIC AMMONIUM CITRATE Mercury Second Supplement to USP37–NF32 ONLINE 01-Apr-2015 USP39–NF34 USP39–NF34
Line 1 of Procedure: Change
Add 5 mL of stannous chloride solution (1 in 10) to each solution
to:
Add 5 mL of Stannous Chloride Solution to each solution


Line 1 of
Procedure: Change
Add 5 mL of stannous chloride solution (1 in 10) to each solution
to:
Add 5 mL of Stannous Chloride Solution to each solution

MINERAL OIL SPECIFIC TESTS/Readily Carbonizable Substances Test <271> Second Supplement to USP37–NF32 ONLINE 01-Apr-2015 USP39–NF34 USP39–NF34
Line 1 of Acceptance criteria: Change
The Sample may turn hazy, but it remains colorless, or shows a slight pink or yellow color, and the Sample does not become darker than the Standard solution.
to:
The oil portion of the Sample may turn hazy, but it remains colorless or shows a slight pink or yellow color, and the acid portion of the Sample does not become darker than the Standard solution.


Line 1 of Acceptance criteria: Change
The Sample may turn hazy, but it remains colorless, or shows a slight pink or yellow color, and the Sample does not become darker than the Standard solution.
to:
The oil portion of the Sample may turn hazy, but it remains colorless or shows a slight pink or yellow color, and the acid portion of the Sample does not become darker than the Standard solution.

PHENYTOIN SODIUM USP Reference standards <11> USP37–NF32 4289 01-Apr-2015 USP39–NF34 USP39–NF34
Line 3 of USP Phenytoin Related Compound A RS: Change
C14H15NO2
to:
C14H13NO2


Line 3 of USP Phenytoin Related Compound A RS: Change

C14H15NO2

to:

C14H13NO2

PURIFIED BENTONITE IDENTIFICATION/A. X-Ray Diffraction <941> USP37–NF32 5862 01-Apr-2015 USP39–NF34 USP39–NF34
Line 4 of Acceptance criteria: Change
from the pattern of Sample B is 1.492 and 1.504 Å.
to:
from the pattern of Sample B is between 1.492 and 1.504 Å.


Line 4 of Acceptance criteria: Change
from the pattern of Sample B is 1.492 and 1.504 Å.

to:
from the pattern of Sample B is between 1.492 and 1.504 Å.

QUETIAPINE FUMARATE IMPURITIES/Organic Impurities USP38–NF33 5102 01-Apr-2015 USP39–NF34 USP39–NF34
Line 2 of Peak identification solution: Change
USP Quetiapine Fumarate Related Compound B RS
to:
USP Quetiapine Related Compound B RS
AND
Line 3 of Peak identification solution: Change
USP Quetiapine Fumarate Related Compound G RS
to:
USP Quetiapine Related Compound G RS







Line 2 of Peak identification solution: Change
USP Quetiapine Fumarate Related Compound B RS

to:
USP Quetiapine Related Compound B RS
AND
Line 3 of Peak identification solution: Change
USP Quetiapine Fumarate Related Compound G RS
to:
USP Quetiapine Related Compound G RS

QUETIAPINE TABLETS PERFORMANCE TESTS/Dissolution <711>/Test 3 USP38–NF33 5104 01-Apr-2015 USP39–NF34 USP39–NF34
Line 7 of Instrumental conditions: Change
10 0mg,
to:
100 mg,
AND
Line 5 of Tolerances: Change
For Tablets labeled to contain 100 mg, 200 mg, 300 mg, or 400 mg:
to:
For Tablets labeled to contain 50 mg, 100 mg, 200 mg, 300 mg, or 400 mg:







Line 7 of Instrumental conditions: Change
10 0mg,
to:
100 mg,
AND
Line 5 of Tolerances: Change
For Tablets labeled to contain 100 mg, 200 mg, 300 mg, or 400 mg:
to:
For Tablets labeled to contain 50 mg, 100 mg, 200 mg, 300 mg, or 400 mg:

RIVASTIGMINE TARTRATE ADDITIONAL REQUIREMENTS/USP Reference Standards <11> First Supplement to USP37–NF32 ONLINE 01-Apr-2015 USP39–NF34 USP39–NF34
Line 2 of USP Rivastigmine Related Compound A RS: Change
Di-p-toluoyl-D-(+)-tartaric acid monohydrate.
C20H20O9 404.37
to:
(+)-Di-(p-toluoyl)-D-tartaric acid.
C20H18O8 386.35




Line 2 of USP Rivastigmine Related Compound A RS: Change
Di-p-toluoyl-D-(+)-tartaric acid monohydrate.

C20H20O9 404.37

to:
(+)-Di-(p-toluoyl)-D-tartaric acid.
C20H18O8 386.35

RIVASTIGMINE TARTRATE CAPSULES ADDITIONAL REQUIREMENTS/USP Reference Standards <11> USP37–NF32 4616 01-Apr-2015 USP39–NF34 USP39–NF34
Line 2 of USP Rivastigmine Related Compound A RS: Change
Di-p-toluoyl-D-(+)-tartaric acid monohydrate.
C20H20O9 404.37
to:
(+)-Di-(p-toluoyl)-D-tartaric acid.
C20H18O8 386.35




Line 2 of USP Rivastigmine Related Compound A RS: Change
Di-p-toluoyl-D-(+)-tartaric acid monohydrate.

C20H20O9 404.37
to:
(+)-Di-(p-toluoyl)-D-tartaric acid.

C20H18O8 386.35

SORBITOL SORBITAN SOLUTION SPECIFIC TESTS USP37–NF32 6197 01-Apr-2015 USP39–NF34 USP39–NF34
Line 1 of pH <791>: Change
4.0–7.0, in a 14% solution of Sorbitol Sorbitan Solution in carbon dioxide-free water
to:
4.0–7.0, in a 14% (w/w) solution of Sorbitol Sorbitan Solution in carbon dioxide-free water


Line 1 of pH <791>: Change
4.0–7.0, in a 14% solution of Sorbitol Sorbitan Solution in carbon dioxide-free water
to:
4.0–7.0, in a 14% (w/w) solution of Sorbitol Sorbitan Solution in carbon dioxide-free water

TREHALOSE IMPURITIES/Heavy Metals, Method I <231> USP37–NF32 6247 01-Apr-2015 USP39–NF34 USP39–NF34
Line 1 of Monitor preparation: Change
Prepare with 2.5 mL of Standard Lead Solution.
to:
Prepare with 2.0 mL of Standard Lead Solution.


Line 1 of Monitor preparation: Change
Prepare with 2.5 mL of Standard Lead Solution.
to:
Prepare with 2.0 mL of Standard Lead Solution.

WITCH HAZEL Limit of tannins USP37–NF32 5177 01-Apr-2015 USP39–NF34 USP39–NF34
Line 3 of Chromatographic system: Change
5.0-mm × 15-cm
to:
4.6-mm × 15-cm


Line 3 of Chromatographic system: Change
5.0-mm × 15-cm
to:
4.6-mm ×
15-cm

AMIODARONE HYDROCHLORIDE ORGANIC IMPURITIES/Procedure 1/Chromatographic system USP38–NF33 2198 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Adsorbent: Change
0.5-mm layer of chromatographic silica gel and fluorescent indicator with maximum absorbance at 254 nm
to:
Suitable layer of chromatographic silica gel and fluorescent indicator with maximum absorbance at 254 nm


Line 1 of Adsorbent: Change
0.5-mm layer of chromatographic silica gel and fluorescent indicator with maximum absorbance at 254 nm
to:
Suitable layer of chromatographic silica gel and fluorescent indicator with maximum absorbance at 254 nm

ATROPINE SULFATE ADDITIONAL REQUIREMENTS/USP Reference Standards <11> USP38–NF33 2325 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 2 of USP Hyoscyamine Related Compound A RS: Change
Norhyoscyamine sulfate; (1R,3r,5S)-8-azabicyclo [3.2.1]oct-3-yl(2S)-3-hydroxy-2-phenylpropanoate. C16H21NO3 275.34
to:
Norhyoscyamine sulfate; (1R,3r,5S)-8-Azabicyclo[3.2.1]octan-3-yl (S)-3-hydroxy-2-phenylpropanoate sulfate (2:1). (C16H21NO3)2 · H2SO4 648.77


Line 2 of USP Hyoscyamine Related Compound A RS: Change
Norhyoscyamine sulfate; (1R,3r,5S)-8-azabicyclo [3.2.1]oct-3-yl(2S)-3-hydroxy-2-phenylpropanoate.
C16H21NO3 275.34
to:
Norhyoscyamine sulfate;
(1R,3r,5S)-8-Azabicyclo[3.2.1]octan-3-yl (S)-3-hydroxy-2-phenylpropanoate sulfate (2:1).
(C16H21NO3)2 · H2SO4 648.77

AZITHROMYCIN SPECIFIC TESTS/pH <791> USP37–NF32 1886 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Sample solution: Change
2 mg/mL from the Sample stock solution in a mixture of methanol and water (1:1)
to:
2 mg/mL obtained by mixing equal volumes of Sample stock solution and water


Line 1 of Sample solution: Change
2 mg/mL from the Sample stock solution in a mixture of methanol and water (1:1)
to:
2 mg/mL obtained by mixing equal volumes of Sample stock solution and water

AZITHROMYCIN IMPURITIES/Organic Impurities/Procedure 1 USP37–NF32 1886 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 6 of Analysis: Change
Calculate the percentages of desosaminylazithromycin and N-demethylazithromycin in the portion of Azithromycin taken:
to:
Calculate the percentages of desosaminylazithromycin, N-demethylazithromycin, and azaerythromycin A in the portion of Azithromycin taken:


Line 6 of Analysis: Change
Calculate the percentages of desosaminylazithromycin and N-demethylazithromycin in the portion of Azithromycin taken:
to:
Calculate the percentages of desosaminylazithromycin, N-demethylazithromycin, and azaerythromycin A in the portion of Azithromycin taken:

BUPROPION HYDROCHLORIDE EXTENDED-RELEASE TABLETS IMPURITIES/Organic Impurities Revision Bulletin (Official October 01, 2014) ONLINE 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Row 4 of Column 1 of Table 16: Change
R,S,S,-Thiomorpholine derivativec
to:
S,R,R,-Thiomorpholine derivativec


Row 4 of Column 1 of Table 16: Change
R,S,S,-Thiomorpholine derivativec
to:

S,R,R,-Thiomorpholine derivativec

BUTABARBITAL SODIUM ORAL SOLUTION ASSAY/Procedure USP38–NF33 2500 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 17 of Analysis: Change
C U = nominal concentration of butabarbital sodium in the Sample solution (µg/mL)
to:
C U = nominal concentration of butabarbital sodium in the Sample solution (mg/mL)


Line 17 of Analysis: Change
C

U
= nominal concentration of butabarbital sodium in the Sample solution (µg/mL)
to:
C

U
= nominal concentration of butabarbital sodium in the Sample solution (mg/mL)

BUTABARBITAL SODIUM TABLETS PERFORMANCE TESTS/Uniformity of Dosage Units <905>/Procedure for content uniformity USP38–NF33 2501 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 18 of Analysis: Change
C U = nominal concentration of butabarbital sodium in the Sample solution
to:
C U = nominal concentration of butabarbital sodium in the Sample solution (mg/mL)


Line 18 of Analysis: Change
C

U
= nominal concentration of butabarbital sodium in the Sample solution
to:
C

U
= nominal concentration of butabarbital sodium in the Sample solution (mg/mL)

CAFFEINE CITRATE INJECTION ASSAY/Procedure USP38–NF33 2520 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 5 of Analysis: Change
Result = (r U /r S ) × C S × (M r1 /M r2 ) × 100
to:
Result = (r U /r S ) × C S × (M r1 /M r2 )


Line 5 of Analysis: Change
Result = (r

U
/r

S
) × C

S
× (M

r1
/M

r2
) × 100
to:
Result = (r

U
/r

S
) × C

S
× (M

r1
/M

r2
)

CAFFEINE CITRATE ORAL SOLUTION ASSAY/Procedure USP38–NF33 2521 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 5 of Analysis: Change
Result = (r U /r S ) × C S × (M r1 /M r2 ) × 100
to:
Result = (r U /r S ) × C S × (M r1 /M r2 )


Line 5 of Analysis: Change
Result = (r

U
/r

S
) × C

S
× (M

r1
/M

r2
) × 100
to:
Result = (r

U
/r

S
) × C

S
× (M

r1
/M

r2
)

CHLORAMPHENICOL SODIUM SUCCINATE Limit of free chloramphenicol USP37–NF32 2285 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 10 of Chromatographic system: Change
Chromatograph the Standard solution, and record the peak areas as directed for Procedure: the relative standard deviation for replicate injections is not less than 2.0%.
to:
Chromatograph the Standard solution, and record the peak areas as directed for Procedure: the relative standard deviation for replicate injections is not more than 2.0%.


Line 10 of Chromatographic system: Change
Chromatograph the Standard solution, and record the peak areas as directed for Procedure: the relative standard deviation for replicate injections is not less than 2.0%.
to:
Chromatograph the Standard solution, and record the peak areas as directed for Procedure: the relative standard deviation for replicate injections is not more than 2.0%.

CHLORDIAZEPOXIDE AND AMITRIPTYLINE HYDROCHLORIDE TABLETS ASSAY/Procedure USP38–NF33 2752 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Buffer: Change
0.20 sodium hydroxide
to:
0.20 N sodium hydroxide


Line 1 of Buffer: Change
0.20 sodium hydroxide
to:
0.20 N sodium hydroxide

CIPROFLOXACIN EXTENDED-RELEASE TABLETS IMPURITIES/Organic Impurities Revision Bulletin (Official October 01, 2014) ONLINE 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 16 of Analysis: Change
M r2 = molecular weight of ciprofloxacin hydrochloride, 367.81
to:
M r2 = molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81
AND
Line 14 of the second Calculate statement in Analysis: Change
M r2 = molecular weight of ciprofloxacin hydrochloride, 367.81
to:
M r2 = molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81







Line 16 of Analysis: Change
M

r2
= molecular weight of ciprofloxacin hydrochloride, 367.81
to:
M

r2
= molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81
AND

Line 14 of the second Calculate statement in Analysis: Change
M

r2
= molecular weight of ciprofloxacin hydrochloride, 367.81
to:
M

r2
= molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81

CIPROFLOXACIN EXTENDED-RELEASE TABLETS PERFORMANCE TESTS/Dissolution <711> Revision Bulletin (Official October 01, 2014) ONLINE 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 13 of Analysis in Test 1: Change
M r2 = molecular weight of ciprofloxacin hydrochloride, 367.81
to:
M r2 = molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81
AND
Line 12 of Analysis in Test 2: Change
M r2 = molecular weight of ciprofloxacin hydrochloride, 367.81
to:
M r2 = molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81
AND
Line 13 of Analysis in Test 3: Change
M r2 = molecular weight of ciprofloxacin hydrochloride, 367.81
to:
M r2 = molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81














Line 13 of Analysis in Test 1: Change
M

r2
= molecular weight of ciprofloxacin hydrochloride, 367.81

to:
M

r2
= molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81

AND
Line 12 of Analysis in Test 2: Change
M

r2
= molecular weight of ciprofloxacin hydrochloride, 367.81

to:
M

r2
= molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81

AND
Line 13 of Analysis in Test 3

Read more
CIPROFLOXACIN EXTENDED-RELEASE TABLETS ASSAY/Procedure Revision Bulletin (Official October 01, 2014) ONLINE 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 17 of Analysis: Change
M r2 = molecular weight of ciprofloxacin hydrochloride, 367.81
to:
M r2 = molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81


Line 17 of Analysis: Change
M

r2
= molecular weight of ciprofloxacin hydrochloride, 367.81
to:
M

r2
= molecular weight of anhydrous ciprofloxacin hydrochloride, 367.81

CITRIC ACID, MAGNESIUM OXIDE, AND SODIUM CARBONATE IRRIGATION ASSAY/Citric Acid USP38–NF33 2844 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 16 of Analysis: Change
C U = nominal concentration of citric acid monohydrate in the Assay preparation for citric acid/citrate assay (units/mL)
to:
C U = nominal concentration of citric acid monohydrate in the Assay preparation for citric acid/citrate assay (µg/mL)


Line 16 of Analysis: Change
C

U
= nominal concentration of citric acid monohydrate in the Assay preparation for citric acid/citrate assay (units/mL)
to:
C

U
= nominal concentration of citric acid monohydrate in the Assay preparation for citric acid/citrate assay (µg/mL)

ESCITALOPRAM TABLETS PERFORMANCE TESTS/Dissolution <711>/Test 2 USP38–NF33 3364 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 13 of Analysis: Change
M r2 = molecular weight of escitalopram oxalate, 405.30
to:
M r2 = molecular weight of escitalopram oxalate, 414.43


Line 13 of Analysis: Change
M

r2
= molecular weight of escitalopram oxalate, 405.30
to:
M

r2
= molecular weight of escitalopram oxalate, 414.43

ESTRADIOL VAGINAL INSERTS PERFORMANCE TESTS/Dissolution <711> USP37–NF32 2866 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 3 of Analysis: Change
Calculate the amount of estradiol (C18H24O2) dissolved:
to:
Record the chromatograms, and measure the responses for the estradiol peak. Construct a calibration curve by plotting the peak response versus concentration of the Standard solutions. Determine the amount of estradiol (C18H24O2) in the Sample solutions from a linear regression analysis of the calibration curve.
Calculate the amount of estradiol (C18H24O2) dissolved:



Line 3 of Analysis: Change
Calculate the amount of estradiol (C18H24O2) dissolved:
to:
Record the chromatograms, and measure the responses for the estradiol peak. Construct a calibration curve by plotting the peak response versus concentration of the Standard solutions.

Read more
EXTENDED PHENYTOIN SODIUM CAPSULES IDENTIFICATION/A. Infrared Absorption—General <197> First Supplement to USP37–NF32 6681 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Sample: Change
6 mg/mL of phenytoin sodium in water from a suitable number of Capsules prepared as follows. Nominally transfer 300 mg of the powder into 50 mL of water in a separator.
to:
300 mg of phenytoin sodium from the contents of Capsules in 50 mL of water in a separator.


Line 1 of Sample: Change
6 mg/mL of phenytoin sodium in water from a suitable number of Capsules prepared as follows. Nominally transfer 300 mg of the powder into 50 mL of water in a separator.
to:
300 mg of phenytoin sodium from the contents of Capsules in 50 mL of water in a separator.

GADOVERSETAMIDE INJECTION Relaxivity <761> USP37–NF32 3121 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Apparatus: Change
Use a mini-NMR spectrometer with suitable sensitivity (see Apparatus under Nuclear Magnetic Resonance <761>).
to:
Use an NMR spectrometer with suitable sensitivity.


Line 1 of Apparatus: Change
Use a mini-NMR spectrometer with suitable sensitivity (see Apparatus under Nuclear Magnetic Resonance <761>).

to:
Use an NMR spectrometer with suitable sensitivity.

GLYCERYL BEHENATE ASSAY/Procedure/Chromatographic system Second Supplement to USP37–NF32 7075 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Column: Change
7.0-mm × 60-cm; 5-µm packing L21
[Note—Two 7.0-mm × 30-cm L21 columns
to:
7.5-mm × 60-cm; 5-µm 100-Å packing L21
[Note—Two 7.5-mm × 30-cm L21 columns




Line 1 of Column: Change
7.0-mm × 60-cm; 5-µm packing L21
[Note—Two 7.0-mm × 30-cm L21 columns
to:
7.5-mm × 60-cm; 5-µm 100-Å packing L21
[Note—Two 7.5-mm × 30-cm L21 columns

HYDROGEN PEROXIDE CONCENTRATE ASSAY/Procedure USP37–NF32 3272 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Sample solution: Change
1 mL of Concentrate, diluted to 100 mL
to:
Weigh about 1 mL of Concentrate in a 100-mL volumetric flask, and dilute with water to volume.


Line 1 of Sample solution: Change
1 mL of Concentrate, diluted to 100 mL
to:
Weigh about 1 mL of Concentrate in a 100-mL volumetric flask, and dilute with water to volume.

HYOSCYAMINE SULFATE USP Reference standards <11> USP37–NF32 3293 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 2 of USP Hyoscyamine Related Compound A RS: Change
(1R,3R,5S)-8-azabicyclo[3.2.1]oct-3-yl(2S)-3-hydroxy-2-phenylpropanoate.
to:
(1R,3r,5S)-8-Azabicyclo[3.2.1]oct-3-yl(2S)-3-hydroxy-2-phenylpropanoate sulfate (2:1).


Line 2 of USP Hyoscyamine Related Compound A RS: Change
(1R,3R,5S)-8-azabicyclo[3.2.1]oct-3-yl(2S)-3-hydroxy-2-phenylpropanoate.
to:
(1R,3r,5S)-8-Azabicyclo[3.2.1]oct-3-yl(2S)-3-hydroxy-2-phenylpropanoate sulfate (2:1).

MESALAMINE RECTAL SUSPENSION OTHER COMPONENTS/Content of Sodium Benzoate (if present) USP38–NF33 4270 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 5 of Analysis: Change
Result = (rU /rS ) × CS × (10/W) × 100
to:
Result = (rU/rS ) × CS × (10/W)


Line 5 of Analysis: Change
Result = (rU
/rS
) × CS
× (10/W) × 100
to:
Result = (rU/rS
) × CS
× (10/W)

METHOTREXATE IMPURITIES/Organic Impurities/Procedure 1: Related Compounds USP37–NF32 3762 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Standard solution A: Change
0.1 μg/mL of USP Methotrexate RS in Solution A, from the Standard stock solution
to:
0.1 µg/mL of USP Methotrexate RS in Solution A, from Standard stock solution A


Line 1 of Standard solution A: Change
0.1 μg/mL of USP Methotrexate RS in Solution A, from the Standard stock solution

to:
0.1 µg/mL of USP Methotrexate RS in Solution A, from Standard stock solution A

PACLITAXEL Related compounds/Test 2 (for Material Labeled as Produced by a Semisynthetic Process) USP37–NF32 4163 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 6 after table in Chromatographic system: Change
the relative standard deviation for replicate injections is not more than 2.0%.
to:
the relative standard deviation for replicate injections is not more than 2.0% for the paclitaxel peak.


Line 6 after table in Chromatographic system: Change
the relative standard deviation for replicate injections is not more than 2.0%.
to:
the relative standard deviation for replicate injections is not more than 2.0% for the paclitaxel peak.

PANCURONIUM BROMIDE ASSAY/Procedure/Chromatographic system USP37–NF32 4176 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Column: Change
4.6-mm × 250-cm; 5-µm packing L1
to:
4.6-mm × 25-cm; 5-µm packing L1


Line 1 of Column: Change
4.6-mm × 250-cm; 5-µm packing L1
to:
4.6-mm × 25-cm; 5-µm packing L1

PAROXETINE HYDROCHLORIDE ADDITIONAL REQUIREMENTS/USP Reference Standards <11> USP38–NF33 4765 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Lines 4 and 7 of USP Paroxetine System Suitability Mixture A RS: Change
hydrochloride (3 S-trans)
to:
hydrochloride (3S-trans)


Lines 4 and 7 of USP Paroxetine System Suitability Mixture A RS: Change
hydrochloride (3 S-trans)
to:
hydrochloride (3S-trans)

PAROXETINE HYDROCHLORIDE IMPURITIES/Limit of 1-Methyl-4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine USP38–NF33 4765 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Line 1 of Standard solution: Change
42 mg/mL
to:
42 ng/mL


Line 1 of Standard solution: Change
42 mg/mL

to:
42 ng/mL

POTASSIUM BITARTRATE IDENTIFICATION USP37–NF32 4346 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Change
C. Identification Tests—General, Tartrate <191>
to:
C. Identification Tests—General, Tartrate <191>: Meets the requirements
AND
Delete subsections:
Sample solution: 1 in 10 solution
Acceptance criteria: Meets the requirements






Change
C. Identification Tests—General, Tartrate <191>


to:
C. Identification Tests—General, Tartrate <191>: Meets the requirements

AND
Delete subsections:
Sample solution: 1 in 10 solution

Acceptance criteria: Meets the requirements

POTASSIUM SODIUM TARTRATE Identification/C: USP37–NF32 4369 01-Feb-2015 USP39–NF34 Second Supplement to USP38–NF33
Change
A solution (1 in 10) responds to the tests for Tartrate <191>.
to:
Responds to the tests for Tartrate <191>.


Change
A solution (1 in 10) responds to the tests for Tartrate <191>.
to:
Responds to the tests for Tartrate <191>.

XLS CSV