Performance Verification Test (PVT)

The USP Performance Verification Test (PVT) assesses the suitable performance of apparatus used in dissolution testing. This assures reliability of dissolution results that reflects the quality of the drug product and not the condition of the test equipment. As such, the PVT in USP General Chapter <711> Dissolution is a core building block for dissolution instrument qualification.

The PVT appraises the suitable performance of the entire apparatus. By using standardized materials and procedures, your laboratory can compare results from your instrument with other laboratories worldwide. Results that do not meet the acceptance criteria can indicate the improper operation of the dissolution assembly, deviation from the procedure, or an error in conducting the test.

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Calculation Tool for the PVT of Dissolution Assemblies

When tailored to your dissolution apparatus and assembly, the PVT calculation tool will measure the geometric mean and coefficient of variation using unrounded dissolution results, compare these values with the respective ranges given in the Certificate, and display a pass/fail message.

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USP Deaeration Procedure by Vacuum Filtration
deaeration procedure

Watch a USP scientist demonstrate how to set up the Deaeration Procedure by Vacuum Filtration.

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Dissolution FAQs

Find answers to a range of questions about dissolution and PVT:

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Dissolution Toolkit

Procedures for Qualification of Apparatus 1 and 2

Provides detailed descriptions of USP best practices for mechanical qualification and the performance verification test (PVT) of USP dissolution test assemblies (basket and paddle).